Each year, tens of thousands of patients undergo invasive surgery to repair perforated eardrums. The surgery, called tympanoplasty, is time consuming, costly, and difficult for patients—many of whom are children. Seeing an opportunity to fill an important unmet medical need, the founders behind Virginia startup Tympanogen have developed a technology aimed at reducing the need for these challenging operations. The product, called Perf-Fix, is a light-cured hydrogel applied in a doctor's office to give the patient's own tissue a scaffold on which to heal and rebuild, circumventing the need for surgical intervention. Co-Founder and CEO Dr. Elaine Horn-Ranney joins us on this episode of our Impact Series to discuss Perf-Fix, what it takes to run a start-up, and some of the many other potential applications for Tympanogen's technology. Learn More about Tympanogen. Check out Tympanogen on the NASA Explorers show, Subscribe on iTunes. Subscribe on Stitcher. Catch up with us on Twitter.